Treatment of osteosarcoma is currently based on high-dose individualized neoadjuvant chemotherapy and surgery. Currently, the 5-year tumor-free survival rate is 50%-70% based on neoadjuvant chemotherapy and the correct surgical protocol. The protocol of surgery should be based on the effect of preoperative chemotherapy and the surgical stage of the tumor. In addition, the wishes of the patient and family, the patient’s age and psychological status, the site and size of the tumor, the condition of the soft tissue and neurovascular bundle, and the foreseeable postoperative function should be taken into consideration. The existing treatments should be applied in a planned and rational way, with the aim to eradicate and control the tumor to the greatest extent, increase the cure rate and improve the quality of life of the patient. The general principle is: life preservation first, then limb preservation, and finally the issue of function. The factors that affect the prognosis of malignant osteosarcoma are as follows: i. Treatment method: The main factor that affects the survival rate of patients is the choice of treatment method, it is very important to have a good treatment method, and at the same time the choice of treatment hospitals and experts should be very careful. The initial treatment is very important and must be carried out in regular bone tumor treatment center. Psychological factors: Many tumor patients have a very negative attitude, which will seriously affect the treatment effect, so it is important to have a good attitude. Family support: Many patients suffering from tumor are the most lonely psychologically, so a word of encouragement and comfort from family will play a great role.