Acne is a chronic inflammatory skin disease of the sebaceous glands of the hair follicles, and is also known as “acne”, “acne”, “pimples”, and “acne”. “Acne is the most common chronic inflammatory skin disease of the sebaceous glands of hair follicles. It is caused by the blockage of sebaceous ducts and pores and the poor outflow of sebum. Since the development of youth, almost everyone has acne on the face or other parts of the body, but some people have a small number of acne and a short period of time. Some people seek careless medical treatment or treat themselves indiscriminately, resulting in a worsening of the condition and more scarring, which is a lifelong regret. Acne is a multifactorial disease. With genetic factors, increased androgen secretion (especially increased dihydrotestosterone in the skin tissue) and the action of microorganisms such as Acinetobacter in the hair follicle opening are the two main factors in the development of acne. The development of human sebaceous glands and sebum secretion are directly governed by androgens. During puberty, the level of androgens increases significantly, stimulating the sebaceous glands and making sebum secretion function abnormally active. The lysozyme, proteolytic enzyme and hyaluronidase produced by Acinetobacter can break down the triglycerides in sebum into free fatty acids. Some of the pustules are due to follicular parasites or secondary infection by white staphylococci. Clinical manifestations of acne The degree of damage caused by acne varies depending on the individual’s response, and its clinical manifestations also vary. Some people develop only mild acne, while others develop severe cysts that leave hyperpigmentation and scars. Therefore, acne is clinically graded according to the severity of the symptoms: Grade I: acne dominated by a small number of papules and pustules, with less than 30 total lesions; Grade II: acne and a moderate number of papules and pustules, with 31 to 50 total lesions; Grade III: a large number of papules and pustules, with 50 to 100 total lesions and less than 3 nodules; Grade IV: nodular/cystic acne or coalescent acne, with more than 100, nodules/cysts greater than 3.