Patients caused by protein-energy malnutrition disease, the clinical manifestation is wasting type, which is characterized by wasting, loss of subcutaneous fat, dry and loose skin and loss of elasticity and luster, wasting severe cases are “skin and bones” like (skin and bones). It is one of the clinical symptoms of protein-energy malnutrition. So, what causes the severe wasting “skin and bones”? The following is a brief introduction: protein-energy malnutrition can be caused by severe protein deficiency and (or) severe energy intake deficiency. There are several causes: 1. Insufficient intake: famine, war or economic backwardness caused by food scarcity or imbalance. Mental disorders, anorexia nervosa and upper gastrointestinal obstruction and other diseases patients can not eat normally as normal. 2.Maldigestion and malabsorption: stubborn and long-term vomiting, diarrhea and digestive and absorption disorders accompanied by other diseases. 3, the body needs to increase the supply of insufficient: mostly seen in infants and children, pregnancy and lactating women. In addition, hyperthyroidism, tumors, tuberculosis, diabetes and other wasting diseases increase the consumption of various nutrients in the body, and protein-energy malnutrition can occur if the supplementation is insufficient.