Lower body wasting type is a clinical symptom of lower body wasting caused by diseases such as progressive lipodystrophy. It is one of the clinical symptoms of progressive lipodystrophy. Progressive lipodystrophy (progressivelipodystrophy) is also known as cephalothoracic lipodystrophy; Simons disease; Seip-Laurence syndrome. It is a rare autonomic disorder characterized by disorders of adipose tissue metabolism. The clinical and histological features are slowly progressive bilateral distribution of largely symmetrical, well-defined, subcutaneous adipose tissue atrophy or loss. The extent of lipodystrophy can be divided into limited lipodystrophy (Simons or cephalothoracic lipodystrophy) and generalized lipodystrophy (Seip-Laurence syndrome). What are the symptoms that are easily confused with it? 1, progressive hemifacial atrophy Progressive hemifacial atrophy is also called Parry-Romberg syndrome. It is a progressive unilateral dystrophic disease of facial tissues, with a few lesions involving the limbs or trunk, called progressive hemifacial atrophy. It is characterized by chronic progressive atrophy of subcutaneous fat and connective tissue on one side of the face without involvement of muscle fibers and, in severe cases, cartilage and bone. Most scholars believe that the disease is related to sympathetic nerve dysfunction, with various causes of sympathetic nerve damage causing neurotrophic impairment of facial tissues, which eventually leads to facial tissue atrophy. Other theories involve local or systemic infection, injury, trigeminal neuritis, connective tissue disease, genetic degeneration, etc. The rate of disease progression is variable. Most cases tend to remit after several to more than 10 years of progression, but concomitant epilepsy may continue. 2, limited-type myotonic dystrophy such as facial-shoulder-humeral type manifested as facial muscle wasting and with muscle weakness EMG suggests muscle damage, subcutaneous fat is still retained. Myotonic dystrophy is a group of primary skeletal muscle necrosis diseases characterized by progressive skeletal muscle weakness caused by genetic factors, clinically manifested mainly as progressive aggravation of skeletal muscle atrophy and weakness of different degrees and distribution. It may also involve the heart muscle. 3.Progressive wasting Progressive wasting refers to short-term progressive, with weight loss before and after the measured weight value control, and there are obvious clothing widening, belt loosening, shoes become larger, as well as subcutaneous fat reduction, muscle weakness, skin laxity, bone protrusion and other circumstantial evidence. 4.Simple upper body wasting type Simple wasting includes somatic wasting and exogenous wasting. The systemic wasting is mainly non-progressive wasting with some heredity. Exogenous wasting is usually influenced by various factors such as diet, living habits and psychology. Inadequate food intake, partial eating, anorexia, missed meals, irregular life and lack of exercise and other dietary and living habits as well as psychological factors such as high work stress, mental tension and overwork are all causes of exogenous wasting. Simple upper body wasting type is a manifestation type of progressive lipodystrophy. Progressive lipodystrophy (progressivelipodystrophy) is a rare autonomic disorder characterized by impaired adipose tissue metabolism. Clinical and histological features are slowly progressive bilaterally distributed largely symmetrical, well-defined, subcutaneous adipose tissue atrophy or disappearance, sometimes combined with limited adipose tissue hyperplasia and hypertrophy. Due to the extent of lipodystrophy, it can be divided into limited lipodystrophy (Simons disease or cephalothoracic lipodystrophy) and generalized lipodystrophy (Seip-Laurence syndrome).