Lower body wasting type is a clinical symptom of lower body wasting caused by diseases such as progressive lipodystrophy. It is one of the clinical symptoms of progressive lipodystrophy. Progressive lipodystrophy (progressivelipodystrophy) is also known as cephalothoracic lipodystrophy; Simons disease; Seip-Laurence syndrome. It is a rare autonomic disorder characterized by disorders of adipose tissue metabolism. The clinical and histological features are slowly progressive bilateral distribution of largely symmetrical, well-defined, subcutaneous adipose tissue atrophy or loss. The extent of lipodystrophy can be divided into limited lipodystrophy (Simons disease or cephalothoracic lipodystrophy) and generalized lipodystrophy (Seip-Laurence syndrome). How is the lower body wasting type diagnosed? The diagnosis can be confirmed by combining three conditions in different ways, such as the disappearance of subcutaneous adipose tissue, the disappearance of adipose tissue on normal biopsy of muscle and bone, and the presence of increased and normal subcutaneous fat disappearance. The diagnosis can be made according to its clinical symptoms. 1, most patients around the age of 5 to 10 years of age onset of disease is more common in women, the onset and progression of the disease are slow at the beginning of the patient more appear facial or upper extremity adipose tissue disappearance, later downward expansion, involving the buttocks and femur, is roughly symmetrical distribution. The course of the disease lasts 2 to 6 years and can stop on its own. The patient’s face shows skin laxity and loss of normal elasticity in both cheeks and temporal recesses, and the fat around the cheeks and orbits disappears so that the patient presents a special face. Some patients can have obvious subcutaneous tissue hyperplasia and hypertrophy in the buttocks and hips, but the hands and feet are often unaffected. 2.Patients can show the basic features of this disease such as the disappearance of adipose tissue, special obesity and normal adipose tissue which coexist and combine in different ways. According to the combination of different ways can be shown as the following types: ① upper body normal lower body obese type; ② upper body wasting lower body obese type; ③ simple upper body wasting type; ④ upper body obese type; ⑤ lower body wasting type; ⑥ whole body wasting type; ⑦ half body obese type. 3, patients can be combined with skin moisture changes abnormal sweating abnormal urinary glucose tolerance reduction, tachycardia vasomotor instability, vascular headache, abdominal pain, vomiting skin and nail dystrophy and other autonomic dysfunction performance, individual cases can be combined with endocrine dysfunction, such as reproductive organ dysplasia thyroid dysfunction, acromegaly and menstrual disorders. Generally, the symptoms gradually stabilize within 5-10 years after the onset of the disease. 4. Patients have normal muscle, bone hair, breast and sweat glands, no muscle strength disorders, most patients’ physical strength is not affected, and somatic and mental development are not affected during the progression of the disease. Recently, it has been reported that Hodgkin’s disease and scleroderma can be complicated. In addition to the involvement of the head, face and neck, trunk and extremities, the whole body, including subcutaneous and peri-visceral adipose tissue, can also be accompanied by hyperlipidemia diabetes, hepatosplenomegaly skin pigmentation heart and muscle hypertrophy, etc.