Patients caused by protein-energy malnutrition disease, the clinical manifestation is wasting type, which is characterized by wasting, loss of subcutaneous fat, dry and loose skin and loss of elasticity and luster, wasting severe cases are “skin and bones” like (skin and bones). It is one of the clinical symptoms of protein-energy malnutrition. So, what are the preventive measures for patients with severe wasting “skin and bones”? The following is a brief introduction: the prevention of protein-energy malnutrition is very important, because the disease occurs mostly in children, so strengthen the health care work of children is the key. Should vigorously promote the new method of child-rearing, promote the correct feeding methods, nutritional guidance, specific measures are as follows. 1, strengthen children’s health care infants and young children grow and develop especially fast, needing more protein and energy than at any age, while the function of the digestive system has not yet been developed, it is easy to cause diarrhea resulting in nutritional disorders. Therefore, it is extremely important to provide guidance on infant and toddler health care, including childcare methods, nutritional guidance, proper care and disease prevention. Vigorously train the nursery staff to improve the business level and prevent the occurrence of malnutrition. 2, prevention and control of other diseases, prevention of various infectious diseases, good immunization program. Correction of congenital anomalies, such as congenital heart disease, cleft lip, cleft palate, hypertrophic pyloric stenosis, etc. 3. Early detection of protein-energy malnutrition should be corrected early. In short, in mild cases, dietary adjustment is the main focus, giving easily digestible and highly nutritious high quality food, animal protein should be more than 1/2 of the total protein, while treating the primary disease and complications, when the condition improves and weight steadily increases, a certain amount of activity can be properly arranged to promote muscle strength recovery. To prevent the occurrence of PEM in patients, risk factors should be assessed, especially for the elderly, frail, suffering from digestive metabolic and wasting diseases to pay attention to nutrition and dietary arrangements, nutritional status monitoring, in order to detect the possibility of PEM at an early stage and take early nutritional intervention to avoid further development of PEM.