Patients caused by protein-energy malnutrition disease, the clinical manifestation is wasting type, which is characterized by wasting, loss of subcutaneous fat, dry and loose skin and loss of elasticity and luster, wasting severe cases are “skin and bones” like (skin and bones). It is one of the clinical symptoms of protein-energy malnutrition. So, how should a patient with severe wasting in the form of “skin and bones” be diagnosed? The following is a brief introduction: Because of the different clinical types of protein-energy malnutrition, for mild, moderate and chronic malnutrition, the diagnosis is more difficult, so the diagnosis needs to be integrated. 1, medical history: according to the dietary situation, to understand the history of insufficient food intake and the history of diseases affecting the digestion and absorption of the body. 2, clinical manifestations: (1) symptoms: early no obvious symptoms, only poor appetite, children’s height and weight slightly below normal. The disease continues to develop, can appear digestive function is reduced, prone to respiratory infections. Severe malnutrition is characterized by emaciation, refusal to eat, indifferent expression, and unresponsiveness, often accompanied by multivitamin deficiency and various complications such as stomatitis, corneal softening, purpura, etc., and finally enters a state of general edema and suppression. (2) signs: ① weight: protein-energy malnutrition will affect the growth and development of children, weight loss. gomez et al. have suggested: Ⅰ degree malnutrition is 75%-90% of the standard weight, Ⅱ degree malnutrition is 60%-75% of the standard weight, Ⅲ degree malnutrition <60%, has diagnostic significance. ② height: height in childhood is a linear rise, protein-energy malnutrition rose continuously slowed, generally compared with the average height of the region for the lower or lower, to have diagnostic value. Under the middle that is height X ± 2S to X ± S, under refers to height X ± 2S below. However, attention should be paid to comprehensive analysis, because normal height can also occur protein-energy malnutrition; conversely, short people are not always malnourished.