During menopause, due to the decline of ovarian function, the secretion of ovarian hormones decreases and ovulation dysfunction, progesterone is insufficient and progresses to complete deficiency. In contrast, estrogen is secreted in high or relatively high amounts at the beginning of the menopausal transition and then enters a long-term deficiency state, with an imbalance in the ratio of estrogen to progesterone at the time of the menopausal transition. The relative deficiency of progesterone and the relatively high level of endogenous estrogen can lead to damage and destruction of joint cartilage, thus accelerating the onset of osteoarthritis. In addition, as age increases, bone weight decreases, from 50-80 years old, for every 10 years, bone weight decreases by 5% in men and 7% in women. The loss of bone mass accelerates significantly during menopause, which can easily lead to osteoporosis, and when the bone mass decreases to a certain degree, the bone strength decreases and subtle bone deformation occurs, and the joint surface becomes uneven, which increases the wear and tear of joints under stresses such as weight bearing and can lead to In turn, the pain caused by osteoarthritis and the patient’s fear of moving the affected limb will also produce or aggravate osteoporosis, thus creating a vicious circle. Furthermore, aging is an inevitable part of any life process, and as we age, the body’s structure and function continue to decline and our susceptibility to disease increases. The bones and joints also undergo physiological aging, and the joints often undergo cartilage degeneration, with some patients experiencing total degeneration of the articular cartilage, resulting in severe pain when the ends of the joints lose the protection of the articular cartilage and come into direct contact with each other during activity.