Clostridium difficile diarrhea is a common geriatric intestinal disease, the main cause of infectious diarrhea in hospitals, related to environmental factors and autoimmune function abnormalities, mainly through the fecal-oral route of transmission, often in elderly people who are hospitalized for a long time and long-term use of antibiotics, patients with colon cancer or other inflammatory bowel disease. 1, environmental factors, medical environment, instruments and other disinfection and sterilization cleaning is not complete, living in poor living and dietary hygiene. 2, autoimmune function abnormalities, especially for long-term hospitalized patients, colon cancer patients, etc. is an important factor to induce C. difficile diarrhea.