Omeprazole is a proton pump inhibitor, which can inhibit the secretion of gastric acid and help improve the symptoms of burning, acid reflux and pain in the stomach caused by increased acid secretion. Long-term use may affect the stomach, intestinal tract and liver function, and may lead to metabolic diseases and malnutrition. Therefore, patients are advised to use the medication reasonably under the guidance of a doctor and not blindly on their own. 1. Stomach effects: prolonged use of omeprazole may cause nausea, dry vomiting, flatulence and other symptoms, and may be accompanied by dry mouth, stomatitis and other symptoms, mostly due to prolonged use of the drug affecting digestive function; 2. Intestinal effects: prolonged use of omeprazole may cause certain effects on the intestinal mucosa, resulting in constipation, abdominal distension, poor bowel movement. 3, liver function damage: long-term use of omeprazole may lead to liver function damage, may appear cholestasis, jaundice, elevated liver function indicators and other phenomena; 4, metabolic diseases and malnutrition: because omeprazole is a proton pump inhibitor, long-term use may affect the body’s absorption of nutrients, resulting in hypoglycemia, hypomagnesemia, hypocalcemia and other conditions. .