Hepatocellular carcinoma is the 3rd most prevalent malignant tumor in China. Due to its insidious onset, most patients are already in advanced stage when they are diagnosed and have lost the opportunity of surgical treatment. Among them, internal radiation therapy with particle implantation has become one of the comprehensive treatment methods for malignant tumors due to its safety and effectiveness. Percutaneous hepatic penetration particle implantation technology can achieve precise localization of the lesion as well as implantation of accurate particle prescription doses to maximize the killing of tumor cells and minimize damage to normal liver tissue. For unresectable mid- to late-stage liver cancer, combined with interventional therapy can also prolong survival time. Particle implantation is suitable for early stage liver cancer patients whose liver function or systemic condition cannot tolerate surgical treatment, those with portal vein cancer thrombosis that cannot be treated by surgery or other treatments, and those early and middle stage liver cancer patients who do not want to undergo surgical treatment. However, when the tumor lesion is more than 5 cm in diameter, the number of multi-nodular lesions exceeds 3, and is accompanied by large amount of ascites, severe jaundice, and very poor coagulation function, other methods should be considered.