Wake up at two or three o’clock in the morning may be physiological reasons, such as mental nervousness, stress, hormone levels, etc., but also may be pathological reasons, such as neurasthenia, depression and other causes. 1. Physiological reasons: mental nervousness, stress, you need to relieve the recent tension and stress factors, adjust the mind. Women in the pre-menstrual or menopausal period, the body’s hormone levels decline, the quality of sleep will also be affected. 2. Neurasthenia: the cause of the disease is not clear, may be related to long-term mental tension, life stress and other psychological factors, mostly in the brain work of the population. The common symptoms of this disease are sleep disorders, manifested as difficulty in falling asleep, poor sleep quality, easy to wake up, etc., can be manifested as two or three o’clock in the morning every day to wake up. 3. Depression: The occurrence of this disease is related to genetic, neurobiochemical, psychosocial, neuroendocrine and other factors, often triggered by the stimulation of stressful life events, pessimistic personality, alcoholism and other factors, leading to early awakening, dreaming, lack of sleep and other sleep disorders, but also low mood, anxiety, slow thinking and other symptoms. When waking up at two or three o’clock in the morning, you need to find out the cause of the disease in time and cooperate with the doctor to avoid delaying the condition.