Diabetic nephropathy is a kidney disease specific to diabetes. The most basic functional structural unit of the kidney is the renal unit, which is composed of the glomerular capsule, glomeruli and tubules. Diabetic nephropathy is the occurrence of sclerosis of the glomerulus, which causes the kidney’s clearance ability to continue to decline, with the subsequent accumulation of toxins, while some useful substances, such as protein, but leak out of the blood vessels with urine excretion, these changes have caused great damage to the body, with the progress of the disease, the function of the kidney is getting worse and worse eventually developed into kidney failure and threaten the lives of patients. Diabetic nephropathy is often asymptomatic in the early stages, and only when the kidneys are not functioning properly do the symptoms appear, so it is easy to be ignored in the early stages. type 1 diabetic patients with diabetic nephropathy can be divided into five stages of kidney damage from mild to severe, progressing by one stage every five years. type 2 diabetic patients with diabetic nephropathy have a similar kidney damage process, except that type 2 diabetic patients have a faster progression of kidney damage than type 1 diabetes. This may be related to the fact that type 2 diabetes occurs mostly in middle-aged and elderly people, and the kidneys have degenerative changes, and are often combined with hypertension and dyslipidemia. Therefore, patients who have diabetes for more than 5 years should be more alert to diabetic nephropathy.