The time of conversion of chronic nephritis to uremia is determined by the degree of glomerular disease, age, the early or late start of treatment, the presence or absence of comorbidities, etc. Therefore, the approximate time elapsed ranges from 5-15 years. Chronic nephritis is a group of bilateral glomerular diseases caused by a variety of reasons, the main clinical manifestations are proteinuria hematuria, hypertension, edema and so on. The disease develops slowly and gradually persists, causing a decline in kidney function, which can eventually lead to renal failure and uremia with continued development. The cause of most patients is unknown, and only 15%-20% are transformed by acute glomerulonephritis, which can occur at any age, but mainly in young and middle-aged men. There are various pathological types of renal biopsy pathology, the most common being thylakoid glomerulonephritis, membranoproliferative glomerulonephritis, focal segmental glomerulosclerosis and membranous nephropathy. The end result is glomerulosclerosis throughout, tubular atrophy, interstitial fibrosis, advanced renal cortical thinning, and renal volume reduction.