Gout is a group of diseases caused by disorders of purine metabolism. In recent years, with the improvement of people’s living standard and the change of diet structure, the incidence of gout in China has increased significantly, especially in middle-aged and elderly people over 40 years old, and more men than women (probably related to diet). At present, it is believed that the cause of this disease is mostly due to congenital enzyme defects in the body, but it may also be closely related to the triggering factors such as improper diet later in life. In patients with long-term uncontrolled gout, it can cause joint deformities and, in more serious cases, the deposition of uric acid crystals in the kidneys, which can lead to damage to kidney function and even uremia. For this reason, attention should be paid to the prevention and treatment of gout disease. 1, clinical manifestations Acute phase: manifestation of joint redness, swelling and pain, the main site for the end of the limbs and other places, and has the tendency of recurrent attacks, laboratory tests increased blood uric acid content (some patients can be normal blood uric acid). Chronic phase: Gout nodule formation (i.e. painful hard lumps formed under the joint skin), joint bone destruction, pain, functional impairment, and may be accompanied by urinary stones and different degrees of renal impairment. 2. Diagnosis and differentiation Diagnosis based on: ① Recurrent episodes (single or multiple) of joint redness, swelling and pain, often waking up with pain during sleep at night. ② Increased blood uric acid (VA) measurement, >400umol/L in men; >350umol/L in women. ③ Gout nodules may be found in hand joints, auricles, etc. Differential diagnosis: The disease should be distinguished from rheumatoid arthritis, rheumatoid arthritis, age-related osteoarthropathy, traumatic osteoarthropathy, cardiac, hepatic and other causes of renal impairment diseases. 3, treatment principles Diet therapy: gout is still lack of effective radical measures, for this reason, in addition to drug therapy, appropriate dietary restrictions, to control the occurrence and development of the disease is of great significance. The following food is divided into three categories, according to different conditions to make dietary arrangements. The first category of food is food with high purine content, estimated to contain 100~1000 mg of purine per 100 grams, which is prohibited for both acute and remission gout patients. These foods include animal brain, heart, kidney, liver and goose meat, grouse, minced meat, thick gravy, broth, mackerel, sand dabs, roe, sea cucumber, dried scallops, oysters, mussels, yeast and alcohol. The second food group contains moderate amount of purine, about 9~100 mg of purine per 100 grams. Since this food group contains moderate amount of purine, patients who are in remission can choose one serving of animal food and one serving of vegetables from it, but the amount of food should not be too much. Animal foods in this category are: fish, meat, poultry and shellfish; plant foods are: dried beans, lentils, lobelia, spinach and mushrooms. The third category of food contains a small amount of purine food, patients can choose to eat at will, without strict control. These foods are: barley, wheat, oats, bread, noodles, rice, cornmeal, starch, cakes, cookies, butter snacks, fruits, eggs, soy milk, tofu, butter, cream, cheese, ice cream, almonds, walnuts, hazelnuts, sugar, jam, honey, vegetable oil, coffee, vegetables, cocoa, soda, soft drinks, snacks made of animal skim or agar, and condiments. Medication: ①Acute attack: you can take anti-inflammatory pain or colchicine under the guidance of a doctor, which can quickly control the redness and painful symptoms of gouty arthritis, and the earlier the medication is used, the better the effect. Colchicine has rapid action, but can cause nausea and vomiting, diarrhea, leukopenia and other adverse reactions, so it should be used under the guidance of a doctor. Although not as fast-acting as colchicine, anti-inflammatory pain relief is also very effective. 25-50 mg per dose, 3 times daily. Reduce the dosage after the symptoms are relieved and stop the drug when the symptoms disappear. ②Relief period: if blood uric acid is increased or normal, long-term application of drugs to inhibit uric acid synthesis can be used, commonly used drugs include: allopurinol, gout lixian, propoxur, etc., which have the effect of controlling hyperuricemia and preventing the recurrence of gout. All of the above drugs need to be reviewed regularly for liver function and white blood cell count.