When liver cancer has spread, the survival time is within 1-3 months, especially in the case of very late spread, such as spread to the abdominal cavity causing large amount of ascites, spread to the brain causing headache, vomiting and limb convulsions, etc.; transit to the lung may cause obvious cough, difficulty in breathing, coughing blood and chest fluid, etc. Therefore, the prognosis of liver cancer is very poor after it has spread, and coupled with the fact that liver cancer is a tumor with very high malignancy and poor treatment effect, it is very difficult to treat liver cancer that has spread. At present, for advanced stage, liver cancer targeted drugs sorafenib, regifenib or lenvatinib, have certain effect. The precursor of targeted drugs is that the patient’s physical condition can tolerate the treatment, and the patient’s liver function requirement is relatively good, which is the case of ChildA grade to use the targeted drugs.