The situation of waking up at four in the middle of the night is not necessarily suffering from a disease, if the patient is resting at 9-10 pm and waking up at four in the middle of the night, about 7-8 hours of rest is also possible, does not mean that the body has a disease. If the patient is resting after 12 pm and waking up at 4 am, or frequently waking up at 4 am, it is necessary to consider whether there is a sleep disorder and neurasthenia, etc. 1.Sleep disorder: it can be caused by a variety of factors, such as too much indoor light, too much noise around, etc. The main performance includes abnormal amount of sleep, less than 5 hours of sleep throughout the night, manifested as difficulty in falling asleep, shallow sleep, easy to wake up or Early awakening, so the patient can wake up at four o’clock in the middle of the night; 2, neurasthenia: mostly due to long-term fatigue, tension, depression, so that patients appear easy to excite the spirit and brain fatigue, often accompanied by emotional abnormalities, sleep disorders, concentration difficulties and other symptoms, can make the patient wake up at four o’clock in the middle of the night, and difficult to fall asleep again. Pay attention to keep a happy mood, avoid excessive worry, can be appropriate outdoor exercise, exercise can make the sympathetic nerve excitement, adrenaline can make the nerve release medium, so as to secrete adrenaline and dopamine, these substances can make the human brain produce a pleasant feeling, can timely relieve people’s stress.