Which oral long-lasting pills for men work well cannot be generalized, but need to decide on the medication according to the specific reasons. The so-called male lasting drugs, that is, drugs to prolong sexual life and improve premature ejaculation, there are two main types, including topical local anesthetics and oral drugs. The common and effective oral medication is dapoxetine hydrochloride, which can effectively improve the central nervous system’s control over ejaculation and can prolong the duration of sex, thus improving the symptoms of premature ejaculation, and its efficiency can reach about 98%. However, there may be side effects such as nausea and vomiting during the use of the drug, but the incidence is not high. In addition, patients who have problems such as premature ejaculation are not advised to use the drug blindly. They can first go to the urology department of a regular hospital for relevant examinations to clarify the specific causes before giving the correct treatment. The vast majority of clinical premature ejaculation is caused by psychological factors, and effective psychotherapy can be administered when necessary.