Primary and secondary liver malignancies are among the common malignancies. Although surgical resection remains the basic treatment for resectable liver tumors, most patients with hepatocellular carcinoma and liver metastases are deprived of treatment due to difficulty in tolerating radiotherapy, tumors that are too diffuse, or inability to undergo surgery. 125I radioactive particle implantation has the advantages of low impact on liver function, high reproducibility, good patient tolerance and precise efficacy, which makes it a very promising treatment method for liver cancer. The advantages of complementary role. (1) Indications and contraindications (1) Hepatocellular carcinoma less than 7 cm in diameter, for larger diameter tumors, TACE should be performed before particle implantation. 2.Recurrence of hepatocellular carcinoma after surgery should not be treated by surgery again. 3. Those who cannot be surgically removed in late local stage. 8. Patients with advanced tumors undergoing tumor reduction therapy or treatment to relieve clinical symptoms. (2) Contraindications: 1. confusion or mental disorder; 2. poor physical condition, unable to cooperate with breathing; 3. coagulation dysfunction or serious bleeding tendency; 4. tissue infection in the puncture path or systemic infection such as sepsis; 5. liver function Child grade C or large amount of abdominal fluid; 6. diffuse hepatocellular carcinoma; 7. extensive extrahepatic metastasis.