Cholinergic augmentation therapy or cholinergic replacement therapy is based on the cholinergic hypothesis that loss of neurons in the cholinergic projection system resulting in decreased brain acetylcholine activity is the primary cause of cognitive impairment in AD. Various drugs have been tried to increase brain cholinergic activity, but only cholinesterase inhibitors (AchE) have been proven to be clinically effective. 1, acetylcholinesterase inhibitors (anti-acetylcholinesterase agents): Anrisin, 5mg/day every night, if necessary, 10mg/day every night. Continue to take the drug, there is improvement in clinical symptoms for about 2 years. The main adverse effects are nausea and vomiting. 2.Esnergy 6-12mg twice a day, orally. The efficacy is comparable to that of Anserine. Adverse reactions are gastrointestinal reactions, nausea, poor sodium, vomiting, etc. 3. Staphylococcus aurantium 0.2mg twice daily. There are many drugs that aim to change different aspects of the pathogenesis of AD in order to alleviate the disease and slow down its progression. 1.Vitamin E and Streptozotocin: both are antioxidants, one alone or in combination with the other has the same effect. 2, Ginkgo biloba preparations: AD and vascular dementia. The effect is better. 3.Glutamate receptor blocker: Memantine: glutamate NMDA receptor antagonist, clinical trials have confirmed that 20mg/day orally is effective and well tolerated in patients with moderate and severe AD; if combined with acetylcholinesterase inhibitors, it can increase the efficacy of the latter. Treatment of psycho-behavioral disorders 1.When patients present with mental, behavioral, emotional, mood disorders and sleep, they should be evaluated correctly, and the causes or triggers should be identified, and the social environment and psychotherapy should be combined with medication. 2.Application of antipsychotic drugs: There are few clinical studies on the application of antipsychotic drugs in patients with dementia, and there are no conventional guidelines or protocols to follow. However, attention should be paid to whether the selected antipsychotic drug has any effect on cognitive function; whether it accelerates or worsens the disease; whether there are interactions with anti-dementia drugs and other drugs (such as cardiovascular drugs) being used, and the possible mutual efficacy and adverse effects.