Anaphylaxis, according to the time of the appearance of allergic reactions, is divided into acute anaphylaxis and slow-onset anaphylaxis. Penicillin allergy is mostly acute anaphylaxis, which mostly develops within half an hour after use, and the condition is urgent and the mortality rate is high. Once the onset of penicillin anaphylaxis, it should be immediately resuscitated in situ, and the specific operation can be divided into the following parts: 1, stop drug administration: let the patient take a flat position, pay attention to keep warm; 2, anti-allergy: the preferred drug is epinephrine intramuscular injection, if no improvement is seen after the first injection or the condition is serious, the amount can be reduced and then injected intravenously; in addition to the application of epinephrine, it is necessary to immediately open intravenous access, timely replenishment of blood In addition to the application of epinephrine, it is necessary to open intravenous access immediately to replenish blood volume. At the same time, apply dexamethasone or hydrocortisone as prescribed by the doctor and add it to glucose solution intravenously. 3. Respiratory support: If there is difficulty in breathing, elevate the upper body appropriately. If loss of consciousness occurs, attention needs to be paid to keep the airway open, prevent the back of the tongue from blocking the airway, and promptly remove secretions from the mouth, nasopharynx and trachea to avoid suffocation. If laryngeal edema occurs, emergency tracheotomy is required, and vital signs are monitored closely. 4. Anti-shock: If respiratory and cardiac arrest occurs, cardiopulmonary resuscitation is performed immediately. 5. Other measures: If blood pressure does not rise significantly, antihypertensive drugs, such as dopamine and norepinephrine, can be applied under the guidance of a doctor. . If significant bronchospasm occurs, nebulized inhalation of salbutamol solution can be used to relieve wheezing symptoms. If complicated by pulmonary edema, cerebral edema or metabolic acidosis, give symptomatic treatment accordingly. Penicillin is one of the common antibiotics and is also a common drug allergen, so it must be used in accordance with medical advice. If there is a history of allergy before, take the initiative to communicate with the doctor and try to change to other antibiotics; if it is used for the first time or by injection, be sure to do a skin test first and use only after the skin test result is normal.