Penicillin-induced shock mainly has the following causes: 1, genetic factors, some patients with hereditary conditions, such patients often appear hypersensitive body, when patients are prone to penicillin allergy; 2, the patient’s own situation is not good, such as congenital dysplasia, insufficient nutrition, and endocrine diseases, such patients can also appear penicillin allergy; 3, patients with long-term chronic diseases, such as diabetes. In the middle of the process of these diseases, patients can also develop allergy. Such as penicillin allergy, mainly because penicillin into the body after degradation into penicillin thiazole aldehyde acid and penicillin enolic acid, can be combined with the body’s proteins, thus forming penicillin thiazole aldehyde acid protein and penicillin enolic acid protein, and these combined proteins, is the real cause of allergic reaction substances. The binding proteins stimulate the body to produce a specific antibody, IgE, which is particularly abundant in allergic patients. When the patient is exposed to penicillin again, the binding proteins can trigger an allergic reaction through IgE on the surface of the target cells, and the whole process of allergic reaction appears to rapidly form a complex of IgE, and the initiating cells are also mast cells, eosinophils, basophils and other cells degranulated. Causes the release of a large number of biological mediators, such as histamine, prostaglandins and other cytokines, which causes rapid dilation of the patient’s vascular bed, causing a decrease in the patient’s blood pressure, leading to shock, and even shortness of breath in some patients due to spasm of bronchial smooth muscle.