Tingling pain in the middle of the chest may be cardiovascular disease, chest wall disease, mediastinal disease, lung and pleural disease, gastrointestinal disease and so on. 1. Cardiovascular diseases: angina pectoris, acute myocardial infarction, ascending aortic coarctation, the anterior region of the heart may appear tingling sensation, knife-like pain, etc.. 2. Chest wall diseases: pinprick pain can occur in the middle rib of chest during acute attack of intercostal neuritis. 3. Mediastinal diseases: acute mediastinitis, mediastinal emphysema, esophageal cancer and other mediastinal diseases can cause stabbing pain in the middle of chest. 4. Lung and pleural diseases: lung infection, lung cancer invading the tissue behind the sternum, dry pleurisy, pleural mesothelioma can also cause stabbing pain in the middle of chest. 5. Digestive diseases: Acute pancreatitis, gastric ulcer and other diseases can cause stabbing pain in the middle of the chest during the attack. It is recommended to go to the hospital for further diagnosis and treatment.