Patients with kidney cancer need to choose the appropriate treatment according to the disease progression. Early stage and most of the middle and late stage kidney cancer can be removed by surgery. If distant metastasis (lung, bone, brain) has already occurred at the time of diagnosis or the patient is not suitable for surgery, targeted drug therapy is also a common treatment option. What are the considerations for patients’ follow-up examinations after kidney cancer surgery? What are the contents of follow-up examinations for patients treated with targeted drugs? Dr. Ye pointed out that post-operative patients with kidney cancer should be reviewed one month after surgery, and then once after 3-6 months, and then once a year. For each review, patients need to do blood routine, urine routine, biochemistry, as well as imaging examination. Checking routine blood can understand whether patients are anemic after surgery; paying attention to creatinine and urea nitrogen in routine urine and biochemical examination can help understand the recovery of renal function after surgery; if the value is high, patients need to visit nephrology department to improve renal function through medication; through renal ultrasound, it can assess whether there is local recurrence of tumor and understand the status of the contralateral kidney at the same time. The most common distant metastasis in kidney cancer patients is lung metastasis, so patients should also have a chest X-ray and lung CT if necessary during the follow-up consultation; in addition, patients with postoperative bone pain should also be evaluated by bone scan to see if bone metastasis has occurred. For patients treated with targeted drugs, Dr. Ye pointed out that a biweekly follow-up should be performed to monitor the therapeutic effect of the drugs and the occurrence of serious adverse reactions during the period of taking the drugs (generally four weeks of taking the drugs and two weeks of stopping the drugs is a course of treatment), with the following precautions: 1. Routine blood and biochemical examinations are recommended every two weeks for patients treated with targeted drugs, so that doctors can assess whether the patient’s bone marrow is suppressed and whether liver function is impaired; 2. Thyroid function check, some patients will have hypothyroidism, some patients will have more severe symptoms, it is recommended to visit endocrinology department for treatment; 3. Hypertension symptoms are common after taking targeted drugs, blood pressure should be controlled below 140/90mmHg with the help of cardiology department, the most commonly used drugs are ACEI/ARB class antihypertensive drugs (i.e. Prilosec and Satan); 4. Hand-foot syndrome. This is one of the most common side effects of taking medications. These patients have severe peeling of the hands and feet, and pain in the hands and feet when they walk or hold things, among other symptoms. Dr. Ye suggested that patients can usually wear thicker socks, wear gloves, apply urea cream or non-irritating emollient cream to protect their skin, and visit a dermatologist if necessary.