For penicillin and cephalosporin, we are not unfamiliar, this is a common drug in the hospital clinic, is not often to go to the hospital patients also know. Now we pay a little attention will find that at present in the hospital clinical use of inexpensive penicillin less, the use of expensive cephalosporin more, there is a cephalosporin to replace the trend of penicillin, and what is the reason for this? 1, penicillin preparations are unstable and easily hydrolyzed by bacterial beta-lactamase, if you want to use, it is necessary to prepare now, so this is mainly for inpatients, usually outpatient use is not much. Unlike cephalosporin, which can be injected or taken orally, it is more convenient in use. 2, because the injection of penicillin is easy to produce allergies, and the incidence of allergic reactions is high, the consequences are serious, doctors are reluctant to prescribe, afraid of medical disputes. 3.The variety of penicillin antibiotics is less than that of cephalosporins, and penicillin is mostly in injectable form, while cephalosporin antibiotics can be taken orally as well as by injection, which is more common in outpatient clinics. 4, penicillin price is low profit, many manufacturers are reluctant to produce, this is also a major reason. The manufacturers have no profit, and now it is still in the background of “medicine to feed the doctor”, it brings too little economic benefits to hospitals and doctors. These factors have contributed to the wider application of cephalosporins, and some cephalosporins, which should not be expensive and effective, have been applied to patients by doctors, resulting in the abuse of antibacterial drugs, something that should not have happened, but has actually happened. Although penicillin is now less used, it has not been completely replaced by cephalosporin, and many doctors and patients want to continue using penicillin.