The pathological features of condyloma acuminata are mainly incomplete keratinization, high hypertrophy of the spiny layer, papillomatous hyperplasia, thickening and prolongation of the epidermal protrusions, the degree of hyperplasia can resemble pseudoepithelioma-like. The spiny cells and basal cells had a considerable number of nuclear divisions and resembled carcinoma. However, the cells were regularly arranged and the boundary between the proliferating epithelium and dermis was clear. It is characterized by the formation of vacuoles in the granular layer and the upper cells of the spiny layer. These vacuolated cells are larger than normal, with light cytoplasmic coloration and large, round, deeply basophilic nuclei in the center. Bushke-loewenstein giant condyloma acuminatum has extreme downward epidermal growth that replaces the underlying tissue and is easily mixed with squamous cells, so multiple biopsies are required. If there is a tendency for slow progression
This is a low-grade malignant process, known as verrucous carcinoma, which must be of great concern to patients and clinicians. The actual genetic diagnosis of condyloma acuminata: To date, HPV is difficult to detect with traditional viral culture and serological techniques, the main experimental diagnostic technique is nucleic acid hybridization. The PCR assay developed in recent years has the advantages of being specific, sensitive, simple and rapid, opening up new avenues for HPV detection.