In general, a solitary thyroid nodule is more likely to be malignant than a multiple nodule or nodular goiter. Patients with the following manifestations should be alerted to the possibility of cancerous nodules. 1.Single thyroid nodules in children under 14 years of age, 10% to 50% of which are malignant, but all are well-differentiated thyroid carcinomas. 2.Single nodule in the thyroid gland in adult males. 3.A thyroid nodule that has existed for many years and has increased significantly in a short period of time. 4.The chance of a single nodule being cancerous is much higher in patients with coastal residence than in patients from endemic goiter areas. Patients who have received radiation therapy to the head and neck during childhood are more likely to have a single thyroid nodule. 6. Physical examination shows hard, irregularly fixed nodules or enlarged ipsilateral cervical lymph nodes, vocal cord paralysis, and hoarseness. 7. Neck radiograph shows cloudy or granular shadows of calcification in the thyroid gland. The border is irregular. The tracheal stenosis caused by thyroid cancer is often normal in left and right diameter, and anterior and posterior diameter can be normal. 8.B ultrasound examination shows solid or cystic solidity with uneven internal echogenicity, unclear and irregular boundary, especially with sandy granular body and calcified foci.