Typical manifestations of panic disorder attacks: 1. Patients suddenly feel palpitations during daily activities such as reading, eating, walking, and performing household chores, as if the heart is about to jump out of the mouth; chest tightness, chest pain, and a feeling of pressure in the chest; or difficulty breathing, blockage of the throat, as if they cannot breathe and are about to suffocate. At the same time, a strong sense of fear appears, as if one is going to die or is about to lose one’s mind. This nervousness makes the patient unbearable. As a result, they scream and call for help. Some patients experience hyperventilation, dizziness, non-real sensation, excessive sweating, facial flushing or pallor, unsteady gait, tremor, numbness of hands and feet, gastrointestinal discomfort, and other symptoms of vegetative hyperexcitability, as well as motor agitation. Such episodes last for a short time, usually 5-20 minutes and rarely more than an hour. The symptoms may resolve on their own or end with yawning, urination, and falling asleep. 2, anticipatory anxiety most patients in the interval after recurrent panic attacks, often worried about the re-occurrence, and therefore anxious, can also appear some symptoms of hyperactivity of the vegetative nerves worried about the onset of the lack of help. 3, help-seeking and avoidance behavior panic attacks, due to the strong sense of fear, patients can not stand, often immediately request emergency help. In the interval of the attack, 60% of patients are worried about not getting help when they have an attack, so they actively avoid some activities, such as not wanting to go out alone, not wanting to go to crowded places, not wanting to travel by car, etc., or going out to be accompanied by others.