I. Symptom criteria Panic disorder attacks need to meet the following 4 items: 1. No obvious trigger for the attack, no relevant specific context, and the attack is unpredictable. 2. In the interictal period, there are no obvious symptoms except the fear of having another attack. 3. The seizure is characterized by intense fear, anxiety, and obvious autonomic symptoms, and often a painful experience such as depersonalization, reality dissolution, near-death fear, or a sense of loss of control. 4. The seizure starts suddenly and reaches its peak rapidly. The patient is clearly conscious during the seizure and can recall it afterwards. II. Severity criteria The patient feels pain because it is unbearable and cannot be relieved. III. Criteria of disease duration At least 3 panic attacks within 1 month, or anxiety secondary to fear of another attack lasting 1 month after the first attack. IV. Exclusion criteria 1. Exclude other mental disorders such as phobia, depression, or somatoform disorders secondary to panic attacks. 2. Exclude panic attacks secondary to somatic disorders such as epilepsy, heart attack, pheochromocytoma, hyperthyroidism, or spontaneous hypoglycemia.