Sleep is an important regulator of hormone secretion, blood glucose regulation and changes in cardiovascular function. It is well known that sleep deprivation predisposes to endocrine disruption. Existing studies suggest that sleep problems have a potential impact on the development of osteoporosis through endocrine. Osteoporosis Osteoporosis is a systemic bone disease characterized by low bone mass and destruction of bone microarchitecture, leading to increased bone fragility and susceptibility to fracture. The disease can occur in different genders and at any age, but is most commonly seen in postmenopausal women and older men. Osteoporosis is a health problem with well-defined pathophysiological, psychosocial and economic consequences. A serious consequence of osteoporosis is the occurrence of fragility fractures, which are fractures that can occur with minor trauma or during daily activities due to decreased bone strength. Osteoporotic fractures greatly increase disability and mortality in the elderly. Pain: Back pain and even peripheral pain, with the aggravation of osteoporosis, the pain increases and activity is limited, and in severe cases, it is impossible to walk and sit normally; 2. Compression of the spine can further lead to deformation of the thorax and compression of organs; 3. Fractures: Fractures can occur with mild trauma or daily activities. Brittle fractures specific to osteoporosis. Commonly found in the thorax, lumbar, hip and wrist. The rate of fracture reoccurrence is also significantly increased. The effect of sleep on the human body for adults over 18 years of age is the optimal daily sleep time of 7-9 hours. However, in today’s society, the length and quality of sleep is decreasing due to work, recreational activities, and psychophysiological diseases. The whole process of night sleep involves the secretion and regulation of a series of human hormones, including growth hormone and melatonin. Either too long or too short a sleep duration can cause disturbances to normal sleep patterns, thus affecting hormone secretion, and poor sleep has now been shown to be significantly associated with the risk of diabetes, obesity and cardiovascular disease. Sleep and osteoporosis It is now generally accepted that too short or too much sleep duration at night is associated with a high risk of bone loss or destruction of bone structure. The lack of sleep affects the function of endocrine metabolism, resulting in elevated levels of glucocorticoids, which can not only inhibit osteogenesis by suppressing the bone marrow matrix, but also accelerate bone resorption and thus affect bone metabolism. Another hormone, growth hormone, is also suppressed, and growth hormone not only induces osteoblast proliferation, but also promotes differentiation. At the same time, too much sleep may also lead to a lack of adequate activity in the body, which affects bone density. Studies on healthy sleep duration have shown that sleeping too short or too long can cause sleep problems. Healthy sleep should take into account the individual’s physiological condition as well as respond to the natural seasonal changes. The best time to sleep is between 11pm and 6am the next morning. Sleep 7-8 hours in summer and 8-9 hours in winter. Add 1-3 hours to this for young children and reduce 1-3 hours for the elderly.