Diffuse connective tissue disease can be treated with non-steroidal anti-inflammatory drugs such as celecoxib, glucocorticosteroids such as methylprednisolone, or anti-rheumatic drugs such as salazosulfapyridine. However, the disease cannot be cured and can only be controlled by medication. Diffuse connective tissue diseases include rheumatoid arthritis, systemic lupus erythematosus, scleroderma, polymyositis/dermatomyositis, etc. Due to the complexity of the etiology and mechanism, the causes of most of these diseases are still unclear, and some of them may be related to genetics, infections and immune system dysfunction. Patients with diffuse connective tissue disease can be treated with non-steroidal anti-inflammatory drugs such as celecoxib and rofecoxib; glucocorticoids such as methylprednisolone; or anti-rheumatic drugs that can modify the condition such as salazosulfapyridine, cyclophosphamide, and leflunomide, as prescribed by the doctor. However, because diffuse connective tissue disease is a rheumatic immune disease, it cannot be cured at present and can only be controlled by medication. Patients with diffuse connective tissue disease need to undergo regular checkups to keep abreast of changes in their condition, in addition to applying medications under the guidance of their doctors. It is recommended that patients with diffuse connective tissue disease should consult the rheumatology and immunology department in time.