Once a pulmonary blister has formed, it is irreversible and there is no specific medication available to treat it. Surgery is the only treatment option. However, the indications for surgery need to be strictly controlled, and asymptomatic, solitary, small-area pulmonary blisters generally do not need to be treated. Patients with primary disease, such as chronic bronchitis, need to be treated with anti-inflammatory or antiviral therapy, depending on the cause. In cases of pulmonary blisters with secondary lung infections, anti-inflammatory treatment with sensitive antibiotics is required based on the results of sputum bacterial culture plus drug sensitivity tests. If the pulmonary blister is large and has clinical symptoms and there is no other combined lung lesion, surgery can be considered. Removing the pulmonary blister can reopen the lung tissue compressed by the blister and increase the effective breathing area to improve the symptoms of chest tightness and shortness of breath. Rupture of pulmonary blisters can cause pneumothorax, which can be treated by thoracentesis or closed chest drainage, but recurrent spontaneous pneumothorax should also be treated surgically to prevent recurrence of pneumothorax. In summary, pulmonary herpes itself cannot be cured by medication, which can only treat its primary cause, and surgery can remove the pulmonary herpes lesion.