Both CT and MRI have certain advantages in diagnosing typical liver cancer, but there is a possibility of misdiagnosis for atypical liver cancer, and DSA has more diagnostic value because of direct imaging of hepatic artery. However, for the few hepatocellular carcinomas that do not use hepatic artery as the main blood supply vessel or those containing less blood vessels, the diagnosis can be easily missed. These three tests are all in the field of imaging, so they cannot be used as the “gold standard” for tumor diagnosis. In clinical work, it is also found that its specificity is poor, that is to say, it has certain false negatives and false positives. In the case of Granny Li, she was highly suspected of having a malignant tumor because of the presence of abdominal and retroperitoneal lymph node metastases. Therefore, PET-CT can be considered as a “radar” for tumor detection at most, and cannot be considered as a “gold standard” for tumor diagnosis. Although the diagnosis of disease depends on various means such as clinical manifestations, physical signs, imaging examinations and body fluid tests, only pathological examination is the “gold standard” for disease diagnosis. Usually, the main ways to obtain pathological diagnosis include surgical resection, mass aspiration or biopsy, collection of chest and abdominal fluid or sputum smear, and other means. Although liver cancer is dangerous, China has made outstanding achievements in early treatment in international attention. Therefore, in the case like Granny Li, puncture biopsy of liver lesions should be performed as early as possible. Only when the tumor is clearly diagnosed at an early stage, it is possible to strive for good treatment results.