Factors that cause deterioration of renal function include the following: (1) insufficient blood volume: it can reduce the glomerular filtration rate and aggravate chronic renal failure; (2) infection: some patients with hypoproteinemia and long-term use of immunosuppressive drugs in nephropathy have decreased body resistance and are prone to complicate respiratory tract infections, and sometimes various diffuse pulmonary inflammatory lesions such as bacteria, viruses, fungi and even mixed infections, and serious infections can often Severe infections can often induce acute interstitial nephritis and aggravate renal damage. Severe infections sometimes force physicians to use nephrotoxic drugs, which can also aggravate renal impairment; (3) overexertion: Some patients do not pay attention to this during the insidious course or when they have renal disease, and their disease progresses after various forms of overexertion (e.g., travel, moving, renovating a new house, etc.), accelerating the deterioration of renal function. In addition, mental factors also play an important role in disease progression; (4) the use of nephrotoxic drugs: such as aminoglycoside antibiotics, sulfonamides and non-steroidal anti-inflammatory drugs and X-ray contrast agents can aggravate renal function damage, it is worth noting that some Chinese medicines (such as Guanmutong, etc.) may also lead to renal tubular damage, should be avoided in excessive use; (5) hypertension: most primary glomerular diseases in (5) hypertension: most primary glomerular diseases appear at different degrees of hypertension in the early stage of the disease or in the stage of disease development, failure to control sodium intake during the course of the disease, clinical persistent moderate or severe hypertension is not easily controlled, accelerating glomerulosclerosis and small renal artery sclerosis, thus accelerating renal function damage, and many patients develop uremia after a hypertensive crisis; (6) hyperlipidemia, hyperglycemia, hypercalcemia and hyperuricemia can also contribute to the deterioration of renal function; (7) Other: long-term massive proteinuria, urinary tract obstruction, pregnancy, etc. can also contribute to the deterioration of renal function.