Acne vulgaris is a chronic inflammatory skin disease of the sebaceous glands of hair follicles common in young people. It is often found on seborrheic areas such as the face and back, and is often characterized by black and white acne, papules, pustules, nodules, scars, and other polypoidal rashes. Acne is a complex skin disease caused by a variety of factors. The pathogenesis of acne is not yet fully understood, but is related to high androgens, increased cortical secretion, hyperkeratosis of the epithelium at the mouth of the hair follicle, Propionibacterium acnes, genetic and environmental factors. Most scholars believe that the high incidence of acne in adolescence is related to the active adrenal function and the secretion of more androgens during this period, and rarely postmenopausal acne is related to the decline in estrogen levels and the relative increase in androgens. Although serum androgen levels influence the occurrence, development and persistence of acne, they are not the only cause. In recent years, the occurrence of lF acne has been associated with the sex hormone receptor (SHR), with increased levels of AR in the follicular sebaceous units or with an imbalance in the ratio between AR and ER or with an increased sensitivity of AR to normal serum androgen levels. 2, the role of microorganisms in the follicular sebaceous gland unit (mainly Propionibacterium acnes) there are a variety of microorganisms in the follicular sebaceous gland unit, such as Propionibacterium acnes, Staphylococcus albicans and oval spores of furfur. At the same time, these bacteria can cause inflammation in the follicular sebaceous gland ducts. 3. Hyperkeratosis of the follicular sebaceous ducts results in the formation of acne. There are several possible causes of hyperkeratosis: (1) a decrease in the epidermal free cholesterol/sulfate cholesterol ratio; (2) an increase in the lipid keratene content on the skin surface of acne patients; (3) a local vitamin A deficiency; and (4) a lack of follicular epithelial linoleic acid. 4, Other factors such as: improper use of cosmetics causing the blockage of sebaceous glands at the mouth of the hair follicle, mental factors, stimulation by pepper, wine and spicy food, excessive intake of sugar, fat and certain drugs can aggravate or promote the development of acne.