Erosive staphyloma is a gestational trophoblastic tumor that evolves from staphyloma. In other words, the blister-like tissue of the gravida invades the myometrium or even penetrates the surface of the uterus to invade the parametrium. Most of the cases of erosive staphyloma occur within 6 months after the removal of the staphyloma, and they are malignant tumors. The common symptom is irregular vaginal bleeding after the gravida is expelled, the blood HCG continues to not drop or turns positive again, and pregnancy is excluded, at this time, it should be considered as erosive gravida, and once diagnosed, chemotherapy is preferred as the main treatment, supplemented by surgery. If there is no fertility requirement, total hysterectomy can be considered, and single drug and single course of adjuvant chemotherapy will be given intraoperatively, and the decline of blood HCG will be monitored after surgery to decide further chemotherapy regimen. For those with fertility requirements, chemotherapy is the mainstay, and the number of courses of chemotherapy is determined by monitoring the changes in blood HCG and imaging to understand the effectiveness of treatment of metastatic lesions. Most of the cases of erosive staphyloma occur within 6 months after the clearance of staphyloma, and it is a malignant tumor. Therefore, after the treatment of staphyloma, strict and effective contraception, regular follow-up, monitoring the decline of blood HCG, and timely consultation when coughing, coughing up blood, and irregular vaginal bleeding occur, in order to diagnose erosive staphyloma early, treat it early, and choose the appropriate treatment plan, which can still improve the prognosis.