Complete staph may be associated with geographic, ethnic, nutritional, socioeconomic factors and gestational age. 1. Dietary deficiency of vitamin A and its precursor carotenoids and animal fats significantly increases the chance of developing staph. Age is another high risk factor, with the incidence of staph in women older than 35 and 40 years of age being 2 and 7.5 times higher than in younger women, respectively. Conversely, the incidence of staphyloma is significantly higher in women younger than 20 years of age. The incidence of recurrent hyperemesis in women with a history of previous pregnancies is 1% and 15%-20%, respectively. The karyotype of complete gravida is 46XX in 90% of cases, which consists of an empty egg with missing or inactivated genetic material in the nucleus fertilized with a haploid sperm that replicates itself into a diploid. The other 10% have a karyotype of 46XY, resulting from the union of an empty egg with two haploid sperm (23X and 23Y) at fertilization. It is now believed that the solitary male origin of the complete staph chromosome is the main cause of trophoblast overgrowth and may be associated with genomic imprinting disorders. Partial staph may be associated with the use of oral contraceptives and menstrual disorders. More than 90% are triploid, with the extra set of chromosomes usually of paternal origin, fertilized by a normal haploid egg and two normal haploid sperm. Alternatively, a normal haploid egg (sperm) is fertilized with a diploid sperm (egg) that has failed meiosis. In both complete and partial gravida, excess paternal genetic material is the main cause of trophoblast proliferation. Very few partial gravidas have a tetraploid karyotype, but the mechanism of formation is not known. There are two types of staph: 1) complete staph: all placental villi are involved, no fetus and its appendages, and the uterine cavity is filled with blisters; 2) partial staph: only some placental villi undergo blister-like degeneration, and there are still viable or dead embryos in the uterine cavity. Some blister-like degeneration was found in 40% of patients in the tissues of spontaneous abortions, but it was not diagnosed as a gravida. The clinical manifestations of gravidity: 1. amenorrhea Because gravidity occurs in the trophoblastic layer of the pregnant egg, there is mostly amenorrhea for 2 to 3 months or longer. Vaginal bleeding is a serious symptom, which is a manifestation of spontaneous abortion of staph. It is a small amount of intermittent bleeding, but it can be interspersed with repeated heavy bleeding. If examined carefully, sometimes blister-like material can be found in the bleeding. The vaginal bleeding apparently comes from the uterus and, in addition to flowing from the vagina, partially accumulates in the uterus; it may also accumulate completely in the uterus for a while, thus prolonging the amenorrhea. Most patients have a uterus larger than that of the corresponding month of menopause, and many patients come to the clinic with a palpable lower abdominal mass (distended uterus or flavin cyst), but there are a few patients whose uterus and month of menopause match or are even smaller than the month of menopause. 4. Abdominal pain The pain can be mild or severe due to rapid enlargement of the uterus and distension, or intrauterine bleeding, which stimulates uterine contraction. 5.Pregnancy toxicity symptoms About half of the patients may develop severe vomiting after menopause, and later on, hypertension, swelling and proteinuria may appear. 6.No fetus Ultrasound monitoring, no fetal sac, fetal heart and fetus are found. Ultrasound scan shows snowflake-like image without fetal image. 7. Ovarian flavinized cysts Ovarian flavinized cysts are often found in some patients and can be detected by double diagnosis or more easily by ultrasound. 8. Hemoptysis Some patients may have hemoptysis or sputum with blood, and the doctor should actively ask if there are any such symptoms. 9.Anemia and infection Repeated bleeding without timely treatment will definitely lead to anemia and its related symptoms, and individual may even die due to bleeding. Repeated bleeding can easily lead to infection, which can be confined to the uterus and adnexa and can lead to sepsis.