The instructions for amoxicillin do not explicitly state that alcohol should not be consumed while taking the drug, but alcohol can interact with many kinds of drugs and cause disulfiram-like reactions, especially antibiotics, so alcohol is also not allowed while taking amoxicillin. Amoxicillin is indicated for respiratory tract infections, urinary tract infections, gastrointestinal tract infections, skin and soft tissue infections caused by sensitive bacteria. It is a broad-spectrum semi-synthetic penicillin with cross-allergy and cross-resistance to penicillins and cephalosporins. It is known that drinking alcohol during the use of cephalosporins can produce a disulfiram-like reaction, and there is cross-allergic reaction between amoxicillin and cephalosporins, so individual patients can also have disulfiram-like reaction when drinking alcohol during the use of amoxicillin. Disulfiram-like reaction is a phenomenon in which the metabolism of ethanol is blocked by taking a drug that contains components that inhibit acetaldehyde dehydrogenase in the liver, resulting in flushing, headache, excessive sweating, nausea, blurred vision, vomiting, hallucinations, chest pain, dyspnea, hypotension, etc. Serious disulfiram-like reactions can be life-threatening. Therefore, disulfiram-like reactions can occur when alcohol is consumed during the administration of such drugs. Drinking alcohol during the application of amoxicillin may also cause disulfiram-like reactions. Therefore, alcohol should not be consumed during the medication and ethanol-containing drugs should be avoided as much as possible. For specific medication, please refer to the clinical situation and follow the guidance of the doctor’s interview.