In diabetic patients, peripheral neuropathy and peripheral vascular disease combined with excessive mechanical stress can cause damage and deformity formation in the soft tissues and bone and joint system of the foot, which can lead to a range of foot problems, from mild neurological symptoms to severe ulcers, infections, vascular disease, Charcot arthropathy and neuropathic fractures. The main manifestations are: ulcers, infections, Charcot arthropathy, toe deformities, etc. Prevention: Active blood sugar control is fundamental to prevention. Patients need to check their feet and shoes daily to detect hidden tissue damage and increased mechanical stress in the shoes, which can be effectively cushioned and provided with supportive protection by modifying the shoes, molded inserts or deepening the shoes. Treatment: Diabetic foot is a disease that requires a multidisciplinary approach. It involves endocrinology, foot and ankle surgery, prosthetic and reconstructive surgery, orthopedics, and vascular surgery. For ulcers and infections, active debridement and drainage, skin grafting or flap soft tissue coverage are required; Charcot arthropathy and toe deformities require surgical correction such as joint osteotomy fusion and tendon lengthening; for vascular occlusion, the limb can be saved and intracavitary treatment such as de-vascularization can be given to improve lower limb circulation, while amputation is inevitable if the limb is necrotic. In short, diabetic foot has now become an increasingly serious social health problem, the previous lack of awareness of diabetic foot, often consider amputation. Studies now find that the five-year mortality rate of diabetic patients after amputation is 39%-68%. That is why limb preservation is now becoming more aggressive worldwide.