1.Cirrhosis Liver cancer mostly occurs on the basis of cirrhosis, and it is often difficult to distinguish the two. The differentiation lies in detailed medical history, physical examination and laboratory tests. Cirrhosis with slow development and recurrent disease, significant liver function impairment and positive serum alpha-fetoprotein (AFP) are mostly suggestive of carcinoma. 2. Extrahepatic tumors adjacent to the liver area Such as gastric cancer, high retroperitoneal tumors in the upper abdomen, from kidney, adrenal gland, colon, pancreatic cancer and retroperitoneal tumors are easily confused with primary liver cancer. Except for fetoprotein, which is mostly negative, the difference in medical history and clinical manifestations, especially ultrasound, CT, MRI and other imaging examinations, and X-ray examination of gastrointestinal tract can make the differential diagnosis. 3.Secondary liver cancer Compared with primary liver cancer, secondary liver cancer has slow development and milder symptoms, most of which are secondary to gastric cancer, followed by lung, colon, pancreas, breast and other cancer foci often metastasized to liver. AFP test is generally negative except for a few cases where the primary cancer is in the digestive tract, which can be positive.