With the westernization of the modern diet, the rising work pressure of young professional women, the accelerated pace of life and irregular diet, the incidence of gallbladder stones in young women is not low. In young women with gallstone disease and preparing for pregnancy, acute cholecystitis attacks are a hidden problem during pregnancy because pregnancy can increase the chance of gallstone disease and can aggravate acute cholecystitis at the same time. The incidence of acute cholecystitis during pregnancy is second only to acute appendicitis, with a prevalence of about 0.8%, and is a common acute abdominal condition in pregnant women, of which 70% are combined with cholelithiasis. Acute cholecystitis can occur at any stage of pregnancy, but is more common in late pregnancy. The diagnosis and treatment of cholecystitis during pregnancy is more difficult because of its specificity. The pain is usually sudden in the right upper abdomen, but can also be seen in the middle of the upper abdomen or under the glabella, with a paroxysmal increase. In late pregnancy, due to the enlarged uterus, early abdominal signs may not be obvious, but only when the inflammation is aggravated and combined with localized peritonitis, right upper abdominal signs may be present. Gallbladder inflammation during pregnancy is usually treated conservatively, but surgery may lead to premature delivery and miscarriage of the fetus during pregnancy. Why are gallstones likely to develop during pregnancy? The level of estrogen and progesterone in the body increases significantly during pregnancy, which, on the one hand, increases the uptake and catabolism of plasma LDL by the liver, thus increasing the cholesterol excreted into the bile duct and increasing the bile cholesterol saturation and bile stone formation index, which easily leads to the formation of gallbladder stones. On the other hand, progesterone causes relaxation of the gallbladder and biliary smooth muscle, resulting in slow emptying of the gallbladder and bile stasis, and estrogen reduces the regulation of sodium by the gallbladder mucosa, which reduces the ability of the gallbladder mucosa to absorb water and affects the concentration function of the gallbladder. What should I do if I am pregnant with gallstone disease? Patients who already have stones before pregnancy, such as: 1) recurrent gallstone disease; 2) gallbladder full of stones, the gallbladder is no longer functional; 3) small stones in the gallbladder, after eating fatty food at any time there is a possibility of dragging; 4) larger symptomatic stones. For the above cases laparoscopic cholecystectomy needs to be performed before pregnancy to avoid the tricky treatment during pregnancy attacks. For women with cholelithiasis who are preparing for pregnancy, they should do the following: 1. perform appropriate physical activities during pregnancy; 2. eat less fatty meat and animal offal, and eat more fresh vegetables and fruits; 3. drink more water, try to eat regularly, and have a reasonable diet structure; 4. ensure sufficient sleep and maintain sufficient energy. If the symptoms of discomfort in the right upper abdomen occur when eating fatty foods during pregnancy, you should go to the hospital for further examination (e.g. B-type ultrasound of gallbladder, etc.).