WHO has included tobacco dependence as a disease in the International Classification of Diseases (ICD-10) (F17.2, a psychoneurological disorder), recognizing tobacco as the greatest threat to human health today. Nicotine dependence, also known as tobacco dependence, has all the characteristics of drug addiction. Psychological dependence, also known as psychological dependence, is commonly referred to as “mind addiction” and is characterized by a strong craving for drugs. Nicotine, like other addictive substances such as heroin, dulcolax, cocaine, and alcohol, binds to nicotinic choline-like receptors in the center, leading to an increase in dopamine release, which in turn brings a sense of calm and pleasure and can satisfy psychological needs. Competitive binding of nicotine to receptors allows prolonged receptor activation, receptor desensitization and upregulation, and when nicotine levels fall, the receptors return to an open state, causing a high contingency state and leading to drug-seeking behavior. Tobacco dependence is a well-defined neuropsychiatric disorder in which repeated nicotine ingestion from tobacco causes changes in neural pathways in the brain, resulting in a strong desire to smoke when quitting, a desire that can weaken or even destroy the resolve to quit. The exact mechanism of tobacco dependence is unclear, with evidence suggesting an association with upregulation of α4β2 nicotinic acetylcholine receptors and functional changes in dopaminergic pathways. Tobacco dependence is a chronic disease with a high recurrence rate. Only a minority of smokers quit completely the first time they quit, and the majority of smokers experience relapse after quitting, requiring multiple attempts to finally quit.