The development of chronic kidney disease is caused by a combination of factors, and its pathogenesis is also very complex, but the incidence of people with the following risk factors is significantly higher and should be highly alert. 1, diabetes 2, hypertension 3, cardiovascular disease 4, family history of kidney disease 5, metabolic diseases (obesity, hyperlipidemia, hyperuric acid, etc.) 6, long-term use of nephrotoxic drugs (non-steroidal anti-inflammatory drugs, antibiotics, etc.) 7, chronic urinary tract infections 8, urinary tract obstruction 9, hypercoagulable state 10, autoimmune diseases (systemic lupus erythematosus, dermatomyositis, scleroderma, etc.) 11, high protein diet 12, smoking 13, excessive alcohol consumption 14, low birth weight 15, age 65 years or older