Solid tumors develop through two stages, local growth and metastasis. Firstly, the tumor forms within the organ, and then the tumor gradually grows and breaks through the organ. There are two ways to break through the organ, one is to grow outside the organ and invade the neighboring organs, for example, kidney cancer grows to the intestinal canal around the kidney; in the other case, the tumor will follow the lymphatic vessels and blood vessels in the organ to reach the distant organs directly, for example, kidney cancer can metastasize to the abdominal lymph nodes along the lymphatic vessels, or to the lungs and liver through the blood vessels. Prostate cancer is a solid tumor and therefore also goes through two stages of local growth and metastasis. After the tumor forms in the prostate, it grows locally and gradually develops to metastasize to organs such as lymph nodes, bones, lungs and liver. However, the growth of prostate cancer is regulated by factors such as androgens. The above two stages are further divided into two different stages according to the tumor’s response to androgens, namely the hormone-sensitive stage and the depot resistance stage, adding up to a total of four stages. At the early stage of disease, most of the patients are hormone sensitive, therefore, most of them can be treated by androgen deprivation method, which is also called “depot treatment”, regardless of whether they have metastasis or not at the time of diagnosis. After a certain period of time, the treatment strategy needs to be adjusted when the treatment becomes resistant to desmotherapy, which is also known as “desmother resistance”.