The principles of antibiotic treatment for infective endocarditis are early and adequate dosage, intravenous administration and combination of drugs. 1. Early and adequate dosage: once infective endocarditis occurs, antibiotic treatment should be carried out as early as possible, the earlier the treatment, the fewer sequelae, antibiotics such as penicillin, gentamicin and other treatments should be given in sufficient quantity to increase the blood concentration, in order to kill the pathogenic microorganisms in the body as comprehensive as possible. 2. Intravenous drug delivery, compared with oral drug delivery, intravenous drug delivery can maximize the blood drug concentration at a higher level to ensure the efficacy of the drug. 3. Combination of drugs: In the absence of clear pathogenic microorganisms, the choice of combination of drugs can maximize the synergistic effect of drugs to kill pathogenic microorganisms. After the pathogenic microorganisms are clearly identified, the types of drugs can be appropriately adjusted to achieve better therapeutic effects. Once infective endocarditis occurs, you should immediately seek medical treatment under the guidance of a doctor, so as not to delay and lead to aggravation of the condition.