Recently, the Department of Thoracic Surgery of Long March Hospital successfully completed the surgical treatment of a patient with congenital heart disease combined with severe infective endocarditis in the right heart system. Endocarditis is a type of disease in which bacteria invade the endocardium, causing intracardiac infection, abscess formation, and structural destruction, which can be fatal or disabling in severe cases, mostly in the left heart system (mitral valve and aortic valve). Infective endocarditis in the right heart system is rare, and pulmonary valve replacement due to infective endocarditis is the first case in the history of our hospital, and according to incomplete literature, less than 10 cases of this type have been reported in China. The patient, Lili, is from Funing, Jiangsu Province, and is only 23 years old, in the flowering age. Unfortunately, Lili was found to have “congenital heart disease” since she was a child, but because of financial reasons, she never received timely treatment. With the gradual growth of her age, she felt more and more insufficient physical strength, and even sometimes panic and shortness of breath after light physical activities; in July this year, she suddenly appeared severe hyperthermia without any reason, her body temperature was repeatedly as high as 39℃, and the local hospital applied a variety of antibiotics for treatment, all without good effect. After being introduced, she came to the thoracic surgery department of Changzheng Hospital in mid-August for treatment. The cardiothoracic surgery team led by Prof. Wang Zhinong conducted a comprehensive and detailed evaluation of Lili and found that Lili had a congenital heart disease of “ventricular septal defect and right ventricular outflow tract stenosis”, combined with severe endocarditis and a bacterial redundant organism attached to the pulmonary valve, which caused the dysfunction of the pulmonary valve. After a series of perfect preoperative preparations, Prof. Wang Zhinong decided to perform surgery on Lili. During the surgery, we found that there were bacterial redundant organisms attached to all three leaflets of her pulmonary valve, the largest of which was 1.5×1.5×1.0 cm, and caused severe destruction of the valve leaflets, which could not be repaired and could only be replaced by pulmonary valve replacement. The whole heart was full of holes. After 6 hours of struggle, the surgery was successfully completed. After the pulmonary valve destruction and pulmonary valve replacement surgery, under the careful treatment and care of the cardiothoracic surgery team of Changzheng Hospital, Lili’s recovery process was very smooth, and she did not have fever again, and her heart function also improved significantly, and she was successfully discharged from the hospital in September. Recently, Lili came back to our hospital for a follow-up examination, and the heart ultrasound showed that the prosthetic valve of the pulmonary valve was working well and the heart function was normal, and the blood test also showed no infection. Lili and her family said happily, “Thank you for giving us a new life at Long March Hospital!