Plasma cell proliferative disorders are a group of hematologic disorders in which monoclonal plasma cells proliferate excessively and produce large numbers of abnormal antibodies. Plasma cells, also known as effector B cells, are lymphocytes derived from white blood cells that normally produce antibodies to help the body fight infections. They are found mainly in the bone marrow and lymph nodes, and most plasma cell disease lesions involve the bone marrow. Most plasma cell disorders involve the bone marrow. When plasma cell aplasia occurs, monoclonal plasma cells overpopulate and produce large numbers of antibody-like molecules that do not help the body defend itself against infections, resulting in a decrease in the production of normal antibodies, which reduces the body’s immunity and increases the risk of infection. If a patient is found to have plasma cell proliferative disease, he or she should go to the hospital in time and actively cooperate with the treatment.