To determine childhood leukemia, clinical signs and symptoms and laboratory tests are used to determine: 1. Clinical symptoms: the most common are recurrent fever, as well as pale skin, anemia, bleeding skin, petechiae, or bleeding gums. Some people may have swollen stomach, swollen liver and spleen, swollen lymph nodes, including swollen lymph nodes in the neck, armpits, groin, etc., and children show clinical symptoms such as joint pain; 2, signs: pale face, swollen lymph nodes and swollen liver and spleen; 3, laboratory tests: routine blood tests show a significant increase or decrease in white blood cells, or a decrease in hematocrit, some with or without There is no thrombocytopenia. As a clinician, to determine whether it is leukemia, the cell morphology will also be checked. If you see obvious naïve cells in the cell morphology, leukemia is very likely. In order to diagnose leukemia, bone aspiration is necessary to confirm the diagnosis, so bone aspiration is the most important indicator for the diagnosis of leukemia. Therefore, we usually encounter many cases in the ward, where doctors consider the presence of leukemia and must confirm the diagnosis by doing bone marrow. Many parents are worried that the bone marrow will be too much for the child to bear and are reluctant to undergo these tests, but without the tests there is no way to confirm the diagnosis and without the diagnosis there is no way to provide the appropriate treatment. Therefore, parents should listen to the doctor’s advice and follow the professional doctor’s recommendation to conduct the appropriate tests and confirm the diagnosis.