The common adverse effects of growth hormone therapy in children with short stature are: growth hormone can cause transient hyperglycemia, which usually returns to normal with prolonged use or after discontinuation of the drug. In clinical application, about 1% of children with short stature have side effects, including local transient reactions at the injection site (such as pain, numbness, redness and swelling) and fluid retention (peripheral edema, arthralgia or myalgia). They rarely affect daily life. Long-term injection of recombinant human growth hormone causes antibody production in a small number of patients, and the antibody binding capacity is low and has no definite clinical significance. However, if the expected therapeutic effect is not achieved, it is possible that the antibody binding is too high and the therapeutic effect is compromised. The following points need to be noted in the process of growth hormone application: 1. It should be used in children with a clear diagnosis under the guidance of a pediatric endocrinologist, or an experienced physician. 2. Children with diabetes mellitus may need to adjust the dose of anti-diabetic drugs. 3. Children with growth hormone deficiency caused by brain tumors or children with a history of intracranial injuries must be closely monitored for the possibility of progression or recurrence of underlying disease. 4. The simultaneous use of corticosteroids can inhibit the growth-promoting effect of growth hormone, therefore, children with adrenocorticotropin deficiency should have their corticosteroid dosage adjusted appropriately to avoid its inhibitory effect on growth hormone. 5. In a few children, hypothyroidism may occur during growth hormone treatment, which should be corrected in time to avoid affecting the therapeutic effect of growth hormone. 6. Individual children may be prone to slippage of the epiphyseal plate of the femoral head, and attention should be paid to the assessment of lameness if it occurs during the treatment period of growth hormone. 7.Sometimes growth hormone can lead to excessive insulin status, therefore, attention must be paid to whether the child has a reduced glucose tolerance. 8. Do not overdose. One injection of too much growth hormone can lead to hypoglycemia followed by hyperglycemia. Long-term overdose may lead to signs and symptoms of acromegaly and other reactions related to growth hormone overdose. 9. The injection site should be frequently changed to prevent fat atrophy.