Often some patients go to the hospital because of headache, vision loss, sexual dysfunction, or fat and other symptoms, find out the saddle region, pituitary gland or tumors in the brain, etc., and surgically removed, thinking that it will be over once and for all. However, after the operation, they will appear cold, memory loss, loss of libido, thirst, drinking, urination, fatigue, lack of spirit, easy to catch a cold, physical decline, no spirit to do things. Multiple tests failed to confirm the diagnosis of adult growth-onset hormone deficiency. Alternatively, some patients with Schieffer’s syndrome after postpartum hemorrhage may also suffer from unexplained osteoporosis, fatigue, poor work ability and social adaptability after timely supplementation of hormones such as sex hormones, thyroid hormones, and adrenocorticotropic hormones, which may also be due to growth hormone deficiency. Some adult patients with chronic unexplained fatigue, in many clinics without success, sometimes by chance to the endocrinology department to check the pituitary-related hormones, but found that the growth hormone is very low, the diagnosis of adult growth hormone deficiency. This is a disease that most patients and doctors overlook. We generally think that growth hormone is mainly related to children’s growth and they will be short after deficiency. In fact, after they stop growing taller, adults also need growth hormone to maintain normal body fat, muscle and bone content. However, some people are unable to produce sufficient amounts such as after pituitary tumor surgery, craniopharyngioma surgery or traumatic brain injury. In addition to fatigue and weakness, growth hormone deficiency can lead to accelerated aging, osteoporosis, spontaneous fractures, increased fat accumulation, cardiovascular disease, and increased dyslipidemia. They require growth hormone replacement therapy. Adult growth hormone deficiency has not been well appreciated, and it is important for both physicians and patients to be aware that patients with intracranial tumors should routinely undergo various hormone tests after surgery to allow for early detection of any problems that may exist. Most adult growth hormone deficient patients will have significant improvement in their quality of life and related indicators after growth hormone supplementation, which is also useful in maintaining a well-proportioned body shape, reducing obesity, improving lipid metabolism, and enhancing muscle strength. And this supplementation is tiny, far less than the dose given to patients with dwarfism, with correspondingly fewer possible side effects.